Acute mountain sickness; prophylactic benefits of antioxidant vitamin supplementation at high altitude. [Results of a prospective double-blind study with alpha-lipoic acid against placebo in alcoholic liver damage] (Ergebnisse einer prospektiven Doppelblindstudie mit Alpha-Liponsäure gegen Plazebo bei alkoholischen Leberschäden). Alpha-lipoic acid (ALA) is a mitochondrial compound involved in energy metabolism. El-Nahas MR, Elkannishy G, Abdelhafez H, Elkhamisy ET, El-Sehrawy AA. Neth.J Med 2010;68(4):158-162. View abstract. Prediabetes. View abstract. View abstract. Invest New Drugs 2012;30(1):200-211. View abstract. View abstract. Yoshida I, Sweetman L, Kulovich S, et al. 2006;15(5):1030-1034. Alpha-lipoic acid has also been used to treat rheumatoid arthritis, Alzheimer's disease, alcoholic liver problems, altitude sickness, heart-related nerve problems, HIV-related brain problems, or eye problems caused by diabetes. Becker, S., Schmidt, C., Berghaus, A., Tschiesner, U., Olzowy, B., and Reichel, O. View abstract. Femiano, F. Burning mouth syndrome (BMS): an open trial of comparative efficacy of alpha-lipoic acid (thioctic acid) with other therapies. Sola, S., Mir, M. Q., Cheema, F. A., Khan-Merchant, N., Menon, R. G., Parthasarathy, S., and Khan, B. V. Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) study. It is not a true vitamin because it can be synthesized in the body and is not necessary in the diet of animals. Biochem Biophys Res Commun 2005;333(2):404-410. View abstract. Clin Toxicol (Phila). Plasma C-reactive protein concentrations in active and passive smokers: influence of antioxidant supplementation. Am J Physiol Heart Circ Physiol 2012;303(10):H1237-H1244. View abstract. View abstract. It is also a potent biological anti-oxidant. Alpha-lipoic acid is essential for certain enzymatic reactions, but there is no official recommended dietary intake of ALA . However, research has shown that alpha-lipoic acid may not be effective in treating these conditions. View abstract. Ned.Tijdschr.Geneeskd. 2008;80(10):27-30. Gurer H, Ozgunes H, Oztezcan S, Ercal N. Antioxidant role of alpha-lipoic acid in lead toxicity. The effects of alpha-lipoic acid when taken alone are unclear. Alpha Lipoic Acid is arguably the best anti-oxidant for regular use, and ThioGel is the finest commercially available alpha lipoic acid product. 2005;10(2):359-368. Am J Physiol 1997;273:E185-91. Alpha-lipoic acid is an antioxidant also known as Acetate Replacing Factor, ALA, Biletan, Lipoicin, Thioctan, and many other names. View abstract. View abstract. Effect of lipoic acid in patient with defective activity of pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase, and branched-chain keto acid dehydrogenase. Larkin, J., Bea, L., and Sharma, A. The use of alpha-lipoic acid in treating mushroom poisoning is controversial. Kim BJ, Hunter A, Brucker AJ, et al. Early research shows that taking alpha-lipoic acid daily for 60 days improves leg pain and weakness due to damage of the sciatic nerve. 1998;46(2):297-306. Carbone M., Pentenero M., Carrozzo M., Ippolito A., Gandolfo S. Lack of efficacy of alpha-lipoic acid in burning mouth syndrome: a double-blind, randomized, placebo-controlled study. 2020: 150(9):2336-2345. Najm, W. and Lie, D. Herbals used for diabetes, obesity, and metabolic syndrome. Yeast, liver, kidney, spinach, broccoli, and potatoes are good sources of alpha-lipoic acid. Arch Biochem Biophys 1959;80(1):86-93. A skin disorder that causes white patches to develop on the skin (vitiligo). However, higher quality research shows that taking alpha-lipoic acid with vitamin E and vitamin C doesn't improve mental function in people with mild-to-moderate Alzheimer disease. Orally administered alpha lipoic acid as a treatment for geographic atrophy: A randomized clinical trial. Konrad, D., Somwar, R., Sweeney, G., Yaworsky, K., Hayashi, M., Ramlal, T., and Klip, A. View abstract. Do not give any herbal/health supplement to a child without the advice of a doctor. Matalon R, Stumpf DA, Michals K, et al. Rutkove, S. B. Combined therapeutic effects of -lipoic acid and mecobalamin on diabetic peripheral neuropathy. Volchegorskii I. Mijnhout, G. S., Alkhalaf, A., Kleefstra, N., and Bilo, H. J. Alpha lipoic acid: a new treatment for neuropathic pain in patients with diabetes? Mohammadshahi M, Zakizadeh E, Ahmadi-Angali K, Ravanbakhsh M, Helli B. View abstract. Treatment of carpal tunnel syndrome with alpha-lipoic acid. Iran J Pharm Res. You may also consider consulting a practitioner who is trained in the use of herbal/health supplements. Cancer chemotherapy and antioxidants. Free Radic Biol Med 1995;19:227-50. High levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia). View abstract. Brennan BP, Jensen JE, Hudson JI, Coit CE, Beaulieu A, Pope HG Jr, Renshaw PF, Cohen BM. J Med Food. Mushroom poisoning. View abstract. Bipolar disorder. Diabetes Res Clin Pract 2013;101(2):99-105. Taking alpha-lipoic acid along with diabetes medications might cause your blood sugar to go too low. Lukaszuk, J. Schultz T. Prawitz A. and Hofmann E. R-Alpha Lipoic Acid Effect on HbA1c in Type-2 Diabetics. Clin Nutr 2009;28(2):192-197. While the body produces alpha-lipoic acid (ALA) naturally, a person … View abstract. It helps the body remove free radicals that damage cells, tissues and organs. Maesaka H, Komiya K, Misugi K, Tada K. Hyperalaninemia hyperpyruvicemia and lactic acidosis due to pyruvate carboxylase deficiency of the liver; treatment with thiamine and lipoic acid. Antiviral Res 2009;81(2):156-165. Alpha lipoic acid (ALA) is synthesized within the mitochondria as a cofactor necessary during mitochondrial energy metabolism. Chinese Journal of Practical Internal Medicine. Arzneimittelforschung 1993;43:1359-62. Heitzer, T., Finckh, B., Albers, S., Krohn, K., Kohlschutter, A., and Meinertz, T. Beneficial effects of alpha-lipoic acid and ascorbic acid on endothelium-dependent, nitric oxide-mediated vasodilation in diabetic patients: relation to parameters of oxidative stress. View abstract. View abstract. Effects of lipoic acid on diabetic peripheral neuropathy. Haramaki N, Assadnazari H, Zimmer G, et al. Schimmelpfennig W, Renger F, Wack R, and et al. View abstract. 2011;11(2):142-148. 2020;74(6):e13493. Palacka, P., Kucharska, J., Murin, J., Dostalova, K., Okkelova, A., Cizova, M., Waczulikova, I., Moricova, S., and Gvozdjakova, A. Complementary therapy in diabetic patients with chronic complications: a pilot study. View abstract. Journal of Practical Diabetology 2008;4:50-51. Ann N Y Acad Sci 1994;738:257-64. A randomized, double-blind, placebo-controlled trial of deprenyl and thioctic acid in human immunodeficiency virus-associated cognitive impairment. Hadzik B, Grass H, Mayatepek E, Daldrup T, Hoehn T. Fata non-accidental alpha-lipoic acid intoxication in an adolescent girl. a-lipoic acid in patients with autosomal dominant polycystic kidney disease. Koh E. H., Lee W. J., Lee S. A., Kim E. H., Cho E. H., Jeong E., Kim D. W., Kim M. S., Park J. Y., Park K. G., Lee H. J., Lee I. K., Lim S., Jang H. C., Lee K. H., Lee K. U. Rees-Jones RW, Larsen PR. View abstract. Tang, J., Wingerchuk, D. M., Crum, B. J Neuroimmunol. Donato, A. J., Uberoi, A., Bailey, D. M., Wray, D. W., and Richardson, R. S. Exercise-induced brachial artery vasodilation: effects of antioxidants and exercise training in elderly men. Haghighatdoost F, Gholami A, Hariri M. Alpha-lipoic acid effect on leptin and adiponectin concentrations: a systematic review and meta-analysis of randomized controlled trials. Conlon BJ, Aran JM, Erre JP, Smith DW. [An endogenous dithiol with antioxidant properties: alpha-lipoic acid, potential uses in cardiovascular diseases]. View abstract. Clin Interv.Aging 2006;1(3):261-265. View abstract. A 52-year-old woman with disabling peripheral neuropathy: review of diabetic polyneuropathy. View abstract. Alpha-lipoic acid is one of the fatty acids from the mitochondrial family of fatty acids that fights against inflammation and oxidation. Alpha lipoic acid or lipoic acid is one of the substances that protect the body from free radical-producing molecules. Zakrzewska, J. M., Forssell, H., and Glenny, A. M. Interventions for the treatment of burning mouth syndrome. [Long-term effect of 3-week intravenous alpha-lipoic acid administration in symptomatic diabetic polyneutropathy with clinical manifestations]. Block G, Jensen C, Dietrich M, et al. View abstract. Diabetologia 1995;38:1425-33. Diabetes Technol Ther, 2000 Autumn; 2(3):401-13. Clin J Pain 2009;25(5):446-452. NATHAN II Study, data on file. View abstract. 6-29-1995;50(1):123-126. Taking a product containing alpha-lipoic acid and other ingredients for up to 2 months before and 1 month after CABG surgery seems to decrease complications from surgery. Alpha lipoic acid benefits include supporting glucose metabloism, and this is perhaps it's best known feature. Because alpha-lipoic acid may help control blood sugar in diabetics, adjustments may be needed to anti-diabetic medication when using alpha-lipoic acid. View abstract. Alpha lipoic acid, or ALA, is a type of antioxidant. Zhou L. Effects of cilostazol and -lipoic acid on diabetic peripheral neuropathy. Gu X. M., Zhang S. S., Wu J. C., Tang Z. Y., Lu Z. Q., Li H., Liu C., Chen L., Ning, G. [Efficacy and safety of high-dose a-lipoic acid in the treatment of diabetic polyneuropathy]. 2011;268(9):1375-1381. View abstract. B., Francesconi, M., Mittermayer, F., Schaller, G., Gouya, G., Wolzt, M., and Pleiner, J. Alpha-lipoic acid improves vascular endothelial function in patients with type 2 diabetes: a placebo-controlled randomized trial. Ou, P., Tritschler, H. J., and Wolff, S. P. Thioctic (lipoic) acid: a therapeutic metal-chelating antioxidant? View abstract. Spisakova, M., Cizek, Z., and Melkova, Z. Ethacrynic and alpha-lipoic acids inhibit vaccinia virus late gene expression. View abstract. Merin JP, Matsuyama M, Kira T, et al. Taking alpha-lipoic acid just before the start of menstruation might reduce period pain by a small amount. Wang J, Song W Huang J & Qu YC. Clin Exp Dermatol 2007;32(6):631-636. View abstract. Rom.J Intern Med 1999;37(3):297-306. View abstract. Journal of Modern Drug Application. 7-17-1995;50(2):253-261. 2019;35(9):782-786. This medicine is useful in the treatment of nerve pain (neuropathic pain). View abstract. Femiano F., Scully C. Burning mouth syndrome (BMS): double blind controlled study of alpha-lipoic acid (thioctic acid) therapy. Rosenberg HR, Culik R. Effect of á-lipoic acid on vitamin C and vitamin E deficiencies. Journal of Traditional Chinese Medicine. Jacob S, Henriksen EJ, Tritschler HJ, et al. Eur J Paediatr Neurol. CONDITIONS OF USE AND IMPORTANT INFORMATION: Saudi Med J 2011;32(6):584-588. 10-18-2008;152(42):2298-2301. Suo LN & Zhang D. Effects of lipoic acid and mecobalamin on diabetic peripheral neuropathy. View abstract. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Sabanovic M, Jasic M, Odobasic A, et al. (check all that apply). Reichel G, Doberenz M, Both R, and et al. Pediatr.Diabetes 2008;9(3 Pt 2):69-73. Berkson BM. 2005;59(6):645-650. Packer L, Tritschler HJ, Wessel K. Neuroprotection by the metabolic antioxidant alpha-lipoic acid. View abstract. When considering the use of herbal supplements, seek the advice of your doctor. Diabetes Care 1999;22:280-7. View abstract. Salinthone, S., Yadav, V., Schillace, R. V., Bourdette, D. N., and Carr, D. W. Lipoic acid attenuates inflammation via cAMP and protein kinase A signaling. Br J Clin Pharmacol 1999;48:819-25. Korkina L. G., Afanas'ef I. According to the National Institutes of Health, antioxidants are substances that help prevent or delay damage to the body's cells. JAMA 10-7-2009;302(13):1451-1458. View abstract. Whether you are treated by a medical doctor or a practitioner trained in the use of natural medicines/supplements, make sure all your healthcare providers know about all of your medical conditions and treatments. Ametov AS, Barinov A, Dyck PJ, et al. Effect of Alpha-lipoic acid amide on hexachlorobenzene porphyria. View abstract. Engagement of the insulin-sensitive pathway in the stimulation of glucose transport by alpha-lipoic acid in 3T3-L1 adipocytes. 2020;14(1):1-6. View abstract. View abstract. Hypertension 2012;59(4):818-824. View abstract. Alpha Lipoic Acid is arguably the best anti-oxidant for regular use, and ThioGel is the finest commercially available alpha lipoic acid product. Gleiter, C. H., Schug, B. S., Hermann, R., Elze, M., Blume, H. H., and Gundert-Remy, U. WebMD does not provide medical advice, diagnosis or treatment. 2009;21(8):423-429. This can increase the risk of preterm birth. View abstract. View abstract. View abstract. View abstract. Lipids Health Dis 2011;10:217. J Am Acad.Nurse Pract. To avoid any interactions among your medications, you might need to get your doses adjusted by your healthcare provider. 2017 Oct 4. Tankova, T., Cherninkova, S., and Koev, D. Treatment for diabetic mononeuropathy with alpha-lipoic acid. 2008;30(7):628-639. Wu YX, Shi F & Ling L. Effects of lipoic acid and prostaglandin E1on diabetic peripheral neuropathy. Nature 7-31-1965;207(996):535. 2020;71:110594. Parente E, Colannino G, Picconi O, Monastra G. Safety of oral alpha-lipoic acid treatment in pregnant women: a retrospective observational study. The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation. It's unclear if the benefits of the combination product are due to alpha-lipoic acid, other ingredients, or the combination. View abstract. Stop taking alpha-lipoic acid and call your doctor at once if you have: low blood sugar--headache, hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, or feeling jittery; or. Eur J Pediatr 1976;122:159-68. Volchegorskii I. Much of the research involving alpha-lipoic acid has been centered on the prevention of diabetes and the management of diabetic nerve pain. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: A meta-analysis. Diabetes Res Clin Pract 2011;92(2):253-260. Mignini, F., Streccioni, V., Tomassoni, D., Traini, E., and Amenta, F. Comparative crossover, randomized, open-label bioequivalence study on the bioequivalence of two formulations of thioctic acid in healthy volunteers. World J Gastroenterol 11-14-2006;12(42):6812-6817. View abstract. Diabetes Care 2012;35(2):196-197. Int J Endocrinol. Jacob, S., Streeper, R. S., Fogt, D. L., Hokama, J. Y., Tritschler, H. J., Dietze, G. J., and Henriksen, E. J. Ramos, L. F., Kane, J., McMonagle, E., Le, P., Wu, P., Shintani, A., Ikizler, T. A., and Himmelfarb, J. Mollo, R., Zaccardi, F., Scalone, G., Scavone, G., Rizzo, P., Navarese, E. P., Manto, A., Pitocco, D., Lanza, G. A., Ghirlanda, G., and Crea, F. Effect of alpha-lipoic acid on platelet reactivity in type 1 diabetic patients. Transl.Res 2010;155(1):6-9. 2009;17:10-11. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. What factors influenced or will influence your purchase? Combination pharmacotherapy for the treatment of neuropathic pain in adults. Integr.Cancer Ther 2006;5(1):83-89. A., Davydova N. G., Endrikhovskii S. N., Shamshinova A. M. [Lipoic acid as a means of metabolic therapy of open-angle glaucoma]. Exp Clin Endocrinol.Diabetes 1999;107(7):421-430. A., Alekseev M. N., Volchegorskaia M. I., Rassokhina L. M. [Effect of alpha-lipoic acid and mexidol on neuro- and the affective status in patients at early stages of diabetic foot syndrome]. View abstract. Bustamante J, Lodge JK, Marcocci L, et al. J Cardiovasc Pharmacol Ther 2012;17(2):139-145. 2010;5(9) View abstract. Biochem Soc Trans 1993;21 ( Pt 3)(3):314S. View abstract. Information from this source is evidence-based and objective, and without commercial influence. View abstract. Wound healing. Koh, J. M., Lee, Y. S., Byun, C. H., Chang, E. J., Kim, H., Kim, Y. H., Kim, H. H., and Kim, G. S. Alpha-lipoic acid suppresses osteoclastogenesis despite increasing the receptor activator of nuclear factor kappaB ligand/osteoprotegerin ratio in human bone marrow stromal cells. Diabetes 1999;48:2045-51. Obes Rev. Byun, C. H., Koh, J. M., Kim, D. K., Park, S. I., Lee, K. U., and Kim, G. S. alpha-Lipoic Acid Inhibits TNF-alpha-Induced Apoptosis in Human Bone Marrow Stromal Cells. Eur J Appl.Physiol 2009;107(4):445-453. 2019;29(10):1009-1011. Differential effects of lipoic acid stereoisomers on glucose metabolism in insulin-resistant skeletal muscle. View abstract. Early research suggests that taking alpha-lipoic acid alone or together with vitamin E for 28 days might reduce symptoms of radiation exposure in children living near areas contaminated with radiation. View abstract. Bratisl.Lek.Listy 2010;111(4):205-211. But it is too soon to know if this interaction occurs. 2017 Dec;37(6):697-701. 2002;8(1):29-35. View abstract. Some early research shows that taking alpha-lipoic acid in combination with a class of drugs called cholinesterase inhibitors might slow mental decline in people with Alzheimer disease better than taking cholinesterase inhibitors alone. B., Diplock A. T. Antioxidant therapy in children affected by irradiation from the Chernobyl nuclear accident. View abstract. Alpha-lipoic acid also does not seem to improve blood sugar levels in people with type 1 diabetes. Gianturco, V., Bellomo, A., D'Ottavio, E., Formosa, V., Iori, A., Mancinella, M., Troisi, G., and Marigliano, V. Impact of therapy with alpha-lipoic acid (ALA) on the oxidative stress in the controlled NIDDM: a possible preventive way against the organ dysfunction? Evans, J. L., Heymann, C. J., Goldfine, I. D., and Gavin, L. A. Pharmacokinetics, tolerability, and fructosamine-lowering effect of a novel, controlled-release formulation of alpha-lipoic acid. Alpha-lipoic acid is an organic compound in the body that acts as a potent antioxidant. Rosa, F. T., Zulet, M. A., Marchini, J. S., and Martinez, J. View abstract. Skalska, S., Kucera, P., Goldenberg, Z., Stefek, M., Kyselova, Z., Jariabka, P., Gajdosikova, A., Klobucnikova, K., Traubner, P., and Stolc, S. Neuropathy in a rat model of mild diabetes induced by multiple low doses of streptozotocin: effects of the antioxidant stobadine in comparison with a high-dose alpha-lipoic acid treatment. View abstract. Zembron-Lacny, A., Slowinska-Lisowska, M., Szygula, Z., Witkowski, K., and Szyszka, K. The comparison of antioxidant and hematological properties of N-acetylcysteine and alpha-lipoic acid in physically active males. Du X., Edelstein D., Brownlee M. Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes. Alpha-Lipoic Acid by Dr. Danielle, Neuropathy Support, Non-GMO, Gluten-Free, Vegan, Soy-Free, Promotes Healthy Blood Sugar, Alpha R Lipoic Acid R-ALA, R-ALA, 120 Veggie Caps 4.5 out of 5 stars 1,987 … 2017 Jun 8 pii:S0261-5614(17)30212-1.View abstract. View abstract. Neurotoxicol Teratol 1990;12:619-22. Journal of Henan University. A rare cause of status epilepticus: alpha lipoic acid intoxication, case report and review of the literature. View abstract. View abstract. ALA occurs naturally in … Estrada, D. E., Ewart, H. S., Tsakiridis, T., Volchuk, A., Ramlal, T., Tritschler, H., and Klip, A. Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin signaling pathway. Boriani F, Granchi D, Roatti G, Merlini L, Sabattini T, Baldini N. Alpha-lipoic acid after median nerve decompression at the carpal tunnel: a randomized controlled trial. Contact Dermatitis 2006;55(1):56-57. Gynecol Endocrinol. View abstract. Hemorrhoids. (Paris) 2008;57(3):161-165. View abstract. A-Lipoic Acid, Acetate Replacing Factor, Acide Alpha-Lipoïque, Acide Alpha-Lipoïque R, Acide DL-Alpha-Lipoïque,Acide Lipoïque, Acide Thioctique, Acide 1,2-dithiolane-3-pentanoïque, Acide 1,2-dithiolane-3-valérique, Acide 5 Valérique (1,2-dithiolan-3-yl), Acide 6,8-dithiooctanoïque, Acide 6,8-Thioctique, Acido Alfa Lipoico, ALA, Biletan, DHLA, Extrait d'acide Alpha-Lipoïque, Lipoic Acid, Lipoicin, R-ALA, R-Alpha-Lipoic Acid, (+-)-1,2-Dithiolane-3-Pentanoic Acid, (R)-Dithiolane-3-Pentanoic Acid,R, S-Alpha Lipoic Acid, (R)-Lipoic Acid, R-Lipoic Acid, RS-Alpha-Lipoic Acid, S-Alpha-Lipoic Acid, S-Lipoic Acid, Sodium-R-Lipoate, Thioctacid, Thioctan,Thioctic Acid. View abstract. Reference: 1. 2002;131(1-2):104-114. View abstract. de Oliveira A. M., Rondó P. H., Luzia L. A., D'Abronzo F. H., Illison V. K. The effects of lipoic acid and a-tocopherol supplementation on the lipid profile and insulin sensitivity of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial. Studies on lipoate effects on blood redox state in human immunodeficiency virus infected patients. Lipoamide dehydrogenase deficiency with primary lactic acidosis: favorable response to treatment with oral lipoic acid. View abstract. Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. View abstract. Alpha Lipoic Acid plays an active role in your body at a cellular level. View abstract. View abstract. View abstract. Sabeel AI, Kurkus J, Lindholm T. Intensive Hemodialysis and Hemoperfusion Treatment of Amanita Mushroom Poisoning. Follow all directions on the product label and package. 2012;41(4):281-287. Zhonghua Yi Xue Za Zhi 2007;87(38):2706-2709. Alpha-lipoic acid shows promise to improve migraine in patients with insulin resistance: a 6-month exploratory study. Ziegler D, Schatz H, Conrad F, et al. Alpha-lipoic acid is a natural antioxidant that can be found in potatoes, spinach, broccoli, liver, kidney, and yeast. Not all possible interactions are listed in this product guide. Khabbazi T., Mahdavi R., Safa J., Pour-Abdollahi P. Effects of alpha-lipoic acid supplementation on inflammation, oxidative stress, and serum lipid profile levels in patients with end-stage renal disease on hemodialysis. Into energy for our cells flow, reduces oxidative stress and inflammatory biomarkers chronic!, you might pass out A. alpha-lipoic acid blocks HIV-1 LTR-dependent expression of resistance! Dysfunction in patients with insulin resistance: a randomized, double-blind, placebo-controlled study the. Benefits of the insulin-sensitive pathway in the therapy of chronic orthostatic hypotension associated with Two Different of! 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