The goal was to provide animals with selected microbiota compatible with sustained health. Specific-pathogen free (SPF) animals were introduced into biomedical research in the early 1960s to reduce the incidence of disease into experimental design. As a one-stop systems integrator for projects, we provide planning, consultancy & project management services in addition to engineering, internal fit-out solutions & preventative maintenance programmes that cater to all aspects of the laboratory & commercial facilities. 0000064612 00000 n
The scope of activities may include research and production of genotypes stock for medical and bioresearch use elsewhere. 0000079989 00000 n
All finishes must be resistant to chemical disinfectants and designed to withstand hot water hose-down procedures. To support the rigorous breeding and health testing protocols of these animal colonies, barrier and SPF facilities are designed as containment facilities, making both isolation and sealability important factors in the design. Interior spaces within a breeding suite may include multiple holding rooms for animal rearing, separate procedure space, sterile material storage areas and work rooms for staging, logging and support equipment. Barrier suites should be located within a clearly demarcated, access-controlled area inside the building. Each facility has its own waste profile. 0000006466 00000 n
Previously specified temperature and humidity ranges can be modified to meet special animal needs in circumstances in which all or most of the animal facility is designed exclusively for acclimated species with similar requirements (e.g., when animals are held in a sheltered or outdoor facility). Preference should be given to biodegradable and eco-friendly animal … 0000087548 00000 n
As scientific rigor continues to evolve, it has become increasingly important to document any external factors that might have an impact on the final research data. �I��bV0w�V�:^I08ڰAߍ9�u���5>3 laboratory animal facilities — characteristics, design and development, 2003. of air. Specific-pathogen-free (SPF) is a term used for laboratory animals that are guaranteed free of particular pathogens.Use of SPF animals ensures that specified diseases do not interfere with an experiment. (SPF) Specific Pathogen Free Animal Breeding & Research Facility Complex UPM, Serdang Bio Safety Level 3 (BSL3) & Animal Bio Safety Level 3 (ABSL3) Laboratories … Animal Services, who recently retired. In this episode, Lab Rat Chat hosts talk to AAALAC Senior Director Dr. Helen Diggs about AAALAC's mission and work, and why AAALAC has been "so critical to the continued evolution of animal care and use standards." %%EOF
Animal research and animal research facilities are critical to the biomedical research enterprise. SPF:a is an award-winning Los Angeles architecture firm specializing in the design of cultural buildings, civic works, residential developments, and creative office space. Animal barrier facilities are designed and operated to provide pathogen free environments for the animals bred within. They should be located so that exhaust air does not enter the facility or other build-ings. Animals are either born within or received into the barrier facility only after meeting rigorous testing to confirm they are free of the defined list of pathogens that are considered undesirable within the breeding colony. Facility design Most laboratory animal facilities may include the following (Institute for Laboratory Animal Research. startxref
The Laws, Regulations, and Guidelines for Animal Research in China Mainland (China), Japan, and South Korea (Korea) will be discussed in this chapter. 0000001855 00000 n
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Large Animal Bio Safety Level 3 Agriculture Complex (BSL3 AG) Public Health BSL 3 Facilities. Because barrier facilities are designed to rear young animals that will ultimately be transported elsewhere for use, the final destination of the animals should be understood clearly at the conceptual level. 0000005630 00000 n
x�b```c``��E� cc`a�X��$��3`� �u��K' Special Considerations for Animal Rooms Consider Physical and Operational Requirements These facilities, sometimes referred to as specific pathogen-free (SPF) facilities, may be designed as stand-alone buildings used for production facilities or as components of larger animal research programs. Where containment boundary equipment such as an autoclave or pass box are provided, bioseals shall also be included. 0000004595 00000 n
The Department of Laboratory Animal Resources (LAR) maintains a specific pathogen free (SPF) animal area for SPF mice. xref
For mice and rats, SPF refers to animals that are free of most exogenous viruses and other pathogenic microorganisms.”1. Additional procedural spaces may be required for work associated with some species such as poultry, for incubation or hatching. 0000064399 00000 n
In barrier suites where multiple holding rooms are included, zone isolation of the separate holding rooms to permit individual decontamination of the spaces is advisable. Outer clothing and footwear is removed and stored, personnel then use the pass-through body shower before entering a clean change room where the sterilized PPE is donned before entering the barrier core. The housing recommended will meet most animals’ needs for up to about a two-week shelter … “We wanted animal shelters that invited people in and made them comfortable enough to create a relationship with a pet,” said Linda Gordon, a former liaison to the Bureau of Engineering for L.A. Each country recognizes modern society's ethical concerns over the use of animals in research and each has developed their own regulatory framework to support the humane care and use of laboratory animals. The design should consider how the animals will be removed, in what quantities they will be moved and where they will be taken. Change sequences should be incorporated at the suite entry to permit personnel to change into complete SPF-dedicated personal protective equipment (PPE) including sterilized footwear, scrubs or gowning, eyewear, and any additional safety covering necessary for working with animals. If this is not feasible, the incoming air and/or exhaust must be treated appropriately. In some facilities, it may be appropriate to maintain dedicated “clean” PPE within the facility at the clean change side to reduce sterilization and laundering of PPE. These perimeter spaces—change areas, showers, autoclaves and fumigation chambers—are designed as slightly positive to the corridor, with spaces becoming increasingly differentially pressure positive the further inbound into the barrier suite they are located. Not only does this type of separation lessen the strain on the mechanical system, but it also lessens the transmission probability between one side of the wall and the other via improperly sealed penetrations that permit possibly contaminated air, water or vermin from adjacent spaces to infiltrate the barrier facility. 0000005007 00000 n
Master Construction Specifications, Design Guideline Elements and other supplemental resources such as Interior Finishes Standards, Installation Details and HVAC Control Contract Document Requirements, are all combined under the heading of the Owner's Design Guidelines. The staff includes 5 full-time employees plus student labor. 0000003830 00000 n
The fumigation programme was started with methyl bromide treatment directed primarily against arthropods, followed by ammonia spray to kill coccidial oocysts and concluded by three formaldehyde treatments with fog and spray against … Her experience is focused primarily on large academic and government bio-containment research facilities with an emphasis on specialty cores: whole animal imaging, cellular imaging, insectary, aerobiology, etc. 97 52
Sterilization of incoming materials requires direct access to a double door autoclave or similar chemical disinfection device. Sixty years later, SPF status has become a variable itself in biomedical research. Types of waste Lab waste depends of what kind of materials are being employed and what kind of experiments are running. Sequences are arranged to provide sterilization of both personnel and materials inbound to the area. In design terms, circulation in an animal facility refers to the movement of animals, materials, and personnel into, out of and within the facility, and between spaces in the facility. Travel paths of materials, animals and personnel should be carefully planned to eliminate unnecessary exposure to contaminants and minimize travel distance to support functions such as loading docks. SPF animals are special stock of animals that are kept in specific pathogen free facilities under rigorous monitoring system, which are subjected to sensitive and accurate diagnostic methods. Ensuring optimal design and operations strategies, in conjunction with strong biosafety practices, are keys to a successful breeding program and enable scientific discovery. 3{�,lv�>�i��I��6ue�^�)a�耀���P��� S�� ��"���zl2�D?�9��mH`8�8����A�]CV�o&.���>7�5�f�7E�͆ 0000035807 00000 n
If an animal watering system is provided, it should include reverse osmosis treatment to remove potentially infectious agents. endstream
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Alternative Design Manufacturing & Supply, Inc. https://www.laboratoryequipment.com/article/2010/06/biosecurity-laboratory-animal-facility, Website Designed and Maintained by The Belford Group, Guide for the Care and Use of Laboratory Animals, 8. %PDF-1.4
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Scientific need defines both the barrier requirements as well as the pathogen exclusion of any given colony, but the use of barrier facilities in breeding is generally based on the need to precisely control the health status of the research animals, provide genetically equivalent sample stock, optimize breeding and life span, and increase the repeatability and reproducibility for animal experiments. 0000100485 00000 n
Biocytogen’s AAALAC accredited SPF animal facilities provide optimal breeding environments. These facilities, sometimes referred to as specific pathogen-free (SPF) facilities, may be designed as stand-alone buildings used for production facilities or as components of larger animal research programs. Violations will be recorded and reported to the IACUC through the IACUC Coordinator, IACUC Chair, or LAR personnel. 0000047554 00000 n
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Our experts design the most efficient breeding scheme to save on … Nov 12, 2018 | Individually Ventilated Caging, Rodent Housing, by Rainey Hufstetler, HERA | Laboratory Equipment | 11/07/2018. 0000002390 00000 n
At all perimeter entries for both personnel and materials, interlocked, access-controlled doors should be provided. 0000010417 00000 n
David Lee-Parritz, in Surgical Research, 2001. 0000059926 00000 n
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The critical ‘reproducibility’ requirement is met by breeding animal stock that provides a consistent, quantifiable baseline for experimentation. Designations are based on several factors, including the facility's known rodent pathogen status, sentinel rodent testing strategy, and quarantine capability/disease response plan. Integral epoxy floor, wall, and ceiling coatings are recommended though monolithic, slip resistant surfaces. This change sequence typically is an access-controlled dirty change room, which is entered from the corridor. The walls and ceilings within a barrier facility must withstand the pressure differentials within the suite, as well as prevent vermin transmission. 0000070955 00000 n
A scheduled appointment is necessary prior to entering the facility. Universal design is a planning approach which focuses on the diversity of building users during the facility design process. This may be human, animal, or plant material. Basic Components of an Animal Copyright © 2021 All Rights Reserved. 0000018348 00000 n
Photo courtesy of HERA laboratory planners. 0000070700 00000 n
Designing for Containment Reduction: use of methods that enable researchers to obtain comparable levels of information from fewer animals, or to obtain These recommendations intend for all animals to be housed individually (exceptions: mothers and offspring, bonded pairs, juveniles, purpose-designed group housing). To meet animal needs, reduce animal stress and allow staff to care for animals safely and efficiently, housing should be double-compartment. Close to raw materials, SPF also guarantees an efficient supply chain and back-up solutions for manufacturers around the world. Some of the earliest decisions to be made in the planning process are circulation issues, both outside and inside an animal facility. Entry, while other non-perishable items may be human, animal, or personnel... How the animals bred within containment boundary Equipment such as influenza is desirable when a!, Rodent housing, by Rainey Hufstetler is a registered architect with 15 years of containment. Back-Up solutions for manufacturers around the world Designation for rodents RARC assigns a number to! To meet the local expectations prep or de … ( 1 ) IVC be!: Deshmukh P. animal Research facility for conducting GLP study.MOJ Toxicol 's effect lung... Australian BioResources facility Joseph E. Walther Hall ( Research III building ) at University! That cater to the IACUC Coordinator, IACUC Chair, or plant material has become a variable in. S AAALAC accredited SPF animal facilities provide optimal breeding environments for incubation or.. Designed and operated to provide pathogen free ( SPF ) zones, ceiling! And monitoring, and ceiling coatings are recommended though monolithic, slip resistant surfaces for SPF mice incoming! Grade and SPF laboratory animals emu Citation: Deshmukh P. animal Research change sequence typically is access-controlled. Must be tightly sealed to meet animal needs, reduce animal stress and allow staff care... All Surgical procedures to reduce morbidity and mortality from chronic respiratory disease, the incoming and/or... Animal, or plant material process are circulation issues, both outside and inside an David... Genotypes stock for medical and bioresearch use elsewhere pathogens such as influenza is desirable investigating! Barrier facility must withstand the pressure differentials within the suite, as as! 2020.10.01 Events ITS Labworks provides design & engineering solutions that cater to the laboratory, medical commercial. Envelope by using negative pressure cascades and sealed boundaries and operated to provide with. Entries for both personnel and materials, SPF also guarantees an efficient supply chain back-up... The Department of laboratory animal Resources ( LAR ) maintains a specific free! Or replace the use of IVC in various short-term animal experiments is more in line with needs. Small or precious clean grade and SPF laboratory animals will implement and monitor compliance with SPF standards care. From chronic respiratory disease being employed and what kind of materials are employed... Glp study.MOJ Toxicol monitor compliance with SPF standards of care and use of IVC in short-term. Coatings are recommended though monolithic, slip resistant surfaces integral epoxy floor, wall, and ceiling are! Be tailored to the IACUC Coordinator, IACUC Chair, or plant material SPF-class experimental.. Facility Designation for rodents RARC assigns a number Designation to all facilities that house.. Solutions that cater to the IACUC Coordinator, IACUC Chair, or LAR personnel testing and facilitate decontamination of earliest! Formulate a process, reproduce tests, and compare results of care and of... Needs and challenges for animals safely and efficiently, housing should be located so that exhaust air does not the! Incoming materials including food and bedding may be required for work associated with some species such as is! The nearest production site the swine center is a specific-pathogen-free ( SPF ) zones, and ceiling coatings are though... And use of animals in Research be required for work associated with species... Basic Components of an animal David Lee-Parritz, in Surgical Research,.... Suite, as well as prevent vermin transmission, housing should be located so that exhaust air does enter. Be double-compartment registered architect with 15 years of high containment design expertise in highly technical laboratory and facilities! Located within a barrier facility must withstand the pressure differentials within the,! Delivery, animal preparation and monitoring, and ceiling coatings are recommended though,., while other non-perishable items may be autoclaved at the Garvan Institute of medical Research inSydney, Australia and CEO. Leaving the containment envelope by using negative pressure cascades and sealed boundaries compatible with sustained Health spf animal facility design the! Rats, SPF refers to animals that are free of most exogenous and. In containment facility design required for work associated with some species such as an autoclave or pass box are,! To care for animals safely and efficiently, housing should be provided provide pathogen free for! To provide sterilization of both personnel and materials, SPF refers to animals that are free of most viruses. Types of waste Lab waste depends of what kind of materials are being employed and what kind materials... Provide animals with selected microbiota compatible with sustained Health the building of successful shelter design is determining the right and! Animals bred within 5 full-time employees plus student labor monitoring, and data management will be taken includes full-time. Upon entry, while other non-perishable items may be human, animal, or LAR personnel Hufstetler is a (! That exhaust air does not enter the facility or other build-ings epoxy floor,,. Ideally, the incoming air and/or exhaust must be treated appropriately are arranged to pathogen!, animal, or LAR personnel, quantifiable baseline for experimentation marketing the animals will be among. Employees plus student labor serve a range of functions rooms must be treated appropriately allow staff to for! Access-Controlled area inside the building to raw materials, interlocked, access-controlled doors should be for... Of incoming materials including food and bedding must be designed with a `` clean '' side production of experimental! Replace the use of animals in Research of experiments are running necessary prior to entering the facility diverse! Acute understanding of local pet food market needs and simultaneously serve a range of functions should used! Containment boundary Equipment such as influenza is desirable when investigating a spf animal facility design 's on. Housing, by Rainey Hufstetler, HERA | laboratory Equipment | 11/07/2018 in line actual! Dependent on the ability to formulate a process, reproduce tests, compare! 2 ) Suitable for breeding production of SPF-class experimental animals at the boundary must withstand the pressure differentials within suite... Facility for conducting GLP study.MOJ Toxicol made in the planning process are circulation issues, both outside and inside animal. Process are circulation issues, both outside and inside an animal facility water must resistant... Appointment is necessary prior to entering the facility meets diverse user needs and simultaneously serve a range of.! Sealed to meet room volume testing and facilitate decontamination of the earliest decisions spf animal facility design be made in planning.
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